Here are the 3 methods that can be used to embed or link a pdf to a microsoft word document. Consult your doctor if you observe any of the following sideeffects, especially if they do not go away. Protamine protamine sulfate classification antidote action binds to heparin, neutralizing it and omaking it ineffective normally within 5 minutes route iv dosage determined bv the heparin dose uiven adult. Protamine is a 9 letter long word starting with p and ending with e. Protamine dosing calculator for reversing heparin and low molecular weight heparins. Each 100 ml contains dobutamine hydrochloride equivalent to 100 mg, 200 mg, or 400 mg of. Protamine dosing guidelines page 2 of 2 guidelines for low molecular weight heparin protamine sulfate neutralizes about 60% of the antifactor xa activity. Protamine prm is a basic nucleus protein with small molecular weight contained in the head of spermatozoa 12, which is important in the packaging of sperm dna 14 and plays an important. Hexalen capsules may cause fetal damage when administered to a pregnant woman. Use protamine during pregnancy only if clearly needed. The safety of protamine sulphate during lactation has not been established.
I mg of protamine neutralizes 90 units of heparin lung. Pdf anaphylactoid reactions to protamine sulfate have been attributed to its. Add brandgeneric drug names to microsoft office word with the clincalc. Protamine total number of words made out of protamine 505 protamine is an acceptable word in scrabble with points. Prosulf 10mgml solution for injection protamine sulphate 10mgml solution for injection 2 qualitative and quantitative composition protamine sulphate 10mgml. Word will convert the pdf to editable text and you can then copy and paste that text into your office document. Although the metabolism of heparin is complex, it may, for the purpose of choosing a protamine dose, be assumed to have a halflife of about 30 minutes after intravenous injection. Many mammalian species have only one protamine protamine 1. Protamine, immunoglobulins, intravenous, antibody, heart surgery.
Microsoft word 2010 includes native functionality that allows you to import, or insert, a pdf file into a word document. This information is believed to be accurate and represents the best information currently available to us. Protamin definition of protamin by medical dictionary. The primary structure of protamine p1, the protamine used for packaging dna in sperm cells, in placental mammals is usually 49 or 50 amino acids long. Pdf anaphylaxis to protamine sulfate mediated by complement. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for proamatine midodrine.
Mar 21, 2018 the following is a list of possible sideeffects that may occur in medicines that contain protamine. The most efficient way to insert pdf into word editable, multipage if you want to insert a multipage pdf into word and edit on the inserted pdf as well, the most efficient way is to do a pdf to word conversion. Discontinue eptifibatide 36 hours prior to surgery or as close to that time as possible. They package the sperm dna into a highly condensed complex in a volume less than 5% of a somatic cell nucleus. Perform platelet transfusions only as required to control bleeding after surgery. This sequence is divided into three separate domains. Protamine definition, any of a group of argininerich, strongly basic proteins that are not coagulated by heat, occurring primarily in the sperm of fish. The easiest ways to insert a pdf into word, either as an image or in an editable format, online or offline.
These sideeffects are possible, but do not always occur. Protamine article about protamine by the free dictionary. Neutralisation of low molecular weight lmw heparins. Package contains 25 vials of ndc 0069600102 ndc 0069600125 both sizes of vials contain tromethamine, usp tris, hydrochloric acid, nf, or sodium hydroxide, nf, and water for injection, usp. Protamine, simple alkaline protein usually occurring in combination with a nucleic acid as a nucleoprotein. For more information, go to edit pdf content in word. Protamine sulphate jordan university of science and. Information for the patient protamine sulphate leo pharma 1400 antiheparin iuml corresponds to 10 mgml solution for injection and infusion protamine sulphate read all of this leaflet carefully before you start using this medicine because it contains important information for.
Protamine sulfate protamine sulfate dose, indications. Protamine is an accepted word in word with friends having 16 points. While, a good pdf to word converter will make things quite easy and simple, allowing users to retain the same layout, format and image quality in the word output as original pdf, to. Protamine sulphate leo pharma 1400 antiheparin iuml. Protamine is not suitable for reversing the effect of oral anticoagulants. The active ingredient of protamine sulfate is the protein protamine sulfate. Convert the pdf into a static image and insert it into a word document. However, this will only insert the text without the original formatting or graphics if any from the pdf file, so it wont look. Use a conversion tool to convert a pdf file to a jpg file. Any of a group of argininerich proteins that bind to and package dna in the sperm nucleus. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for tegretol carbamazepine. Each mg of protamine sulfate neutralizes approximately 100 usp heparin units. Protamine a protein of low molecular weight that occurs in the. Effect of site of venous protamine administration, previously.
Single doses of intravenous protamine result in the formation. Protamine insulin definition of protamine insulin by the. Click insert to insert the images into the word document. Administered once or twice daily, nph neutral protamine hagedorn insulin lowers blood glucose within 1 to 2 hours after administration and exerts a peak effect at 6 to 10 hours. Cardiovascular risk associated with rapid infusion rates see full prescribing information for complete boxed warning the rate of intravenous cerebyx administration should not exceed 150 mg phenytoin sodium equivalents pe per minute in adults and 2 mg pekgmin or 150 mg pemin, whichever is slower in pediatric patients because of the risk of severe hypotension and cardiac.
On its own, protamine acts as a weak blood thinner anticoagulant, but when it interacts with heparin, it neutralizes the heparin bloodthinning effect. Open the word document and select insert on the ribbon in the text group click the dropdown arrow for object and select object the object dialog box will appear select create from file choose browse and select the pdf file to embed the file location will now appear. Other typical protamines include sturine, from sturgeon, and clupeine, from herring sperm. A sperm cell can contain up to 50,000 toroidshaped structures in its nucleus with each toroid containing about 50 kilobases. Protamine is an injectable medication that is derived from fish sperm. Helicobacter pylori igg antibody measurement, nci thesauruscdisc. Protamine sulfate 1 mg will usually neutralise heparin 100 units. The optimal protaminetoheparin ratio in cardiac surgery has, however, not yet been. Purification and analysis of protamine request pdf researchgate. It is used to reverse the effects of the bloodthinning drug heparin when reversal is desired. Protamine sulphate injection 1% drug medicine information.
Hexalen capsules adjusted as clinically indicated see dosage and administration. Dec 31, 2019 protamine sulfate injection, usp is a sterile, isotonic solution of protamine sulfate. Regardless of the heparin or lmwh dosage, the maximum recommended. Category d hexalen capsules has been shown to be embryotoxic and teratogenic in rats and rabbits when given at doses 2 and 10 times the human dose. In gross excess, protamine itself acts as an anticoagulant. Information for the patient protamine sulphate leo pharma 1400 antiheparin iuml corresponds to 10 mgml solution for injection and infusion protamine sulphate read all of this leaflet carefully before you start using this medicine because it contains important information for you. Protamine calculator for heparin and low molecular heparin. Drug guideline guideline title nsw agency for clinical.
If youre looking to insert the contents of your pdf file into an office file, as opposed to simply inserting the pdf as an attachment, then your best bet is to open that pdf with word 20 or 2016. Pdf, or portable document format, files are commonly used for product specification sheets and user manuals. Protamine sulfate is used in hospitals to counteract the effect of heparin given before and after surgery and after. Contain spills with an inert absorbent material such as soil, sand or oil dry.
Below, you will find out how to insert a pdf into a word file within seconds, either as an image or in a format that is editable. This calculator determines a neutralizing dose of protamine to reverse both ufh. A number of japanese patents exist for the use of protamine as food. Protamine sulfate injection, usp is a sterile, isotonic solution of protamine sulfate. Pdf the important role of protamine in spermatogenesis and. Risk factors include high dose or overdose, rapid administration see warnings and dosage and administration, repeated doses, previous. However, we make no warranty of merchantability or any other warranty. Avoid runoff into storm sewers, ditches, and waterways.
The contents of the pdf will not be editable, nor will they change if the source file is updated using this method. A dose of 1mg per 100 units is usually recommended but. According to the manufacturer, it is unknown whether protamine is excreted into human breast milk. You can also import a portion of text from the pdf file using the insert object tool, and drop it into the word document. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Protamine definition is any of various strongly basic proteins of relatively low molecular weight that are rich in arginine and are found associated especially with dna in place of histone in the sperm cells of various animals such as fish. Factors, and preoperative use of aspirin on acute protamineinduced. Protamine sulfate protamine protamines s injection, usp is indicated in the treatment of heparin overdosage dosage and administration. Protamine sulfate is a polycationic, highly positively charged protein derived from salmon sperm protein, with a molecular weight of approximately 4500 daltons. Protamine dosing guidelines guidelines for unfractionated. All patients had radial artery catheters inserted percu. Each mg of protamine sulfate protamine protamines s will neutralize approximately 90 usp units of heparin activity derived from beef lung tissue or about 115 usp units of heparin activity derived from porcine intestinal mucosa. Embed pdf in word embed a pdf document into microsoft word. Consider dialysis if webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In other words, a 250mg dose yielded consistently lower. Anticoagulant and sideeffects of protamine in cardiac surgery.
Protamine sulfate an overview sciencedirect topics. Protamine definition of protamine by medical dictionary. Neurologic toxicity has been reported to be reversible when therapy is discontinued. During the formation of sperm, protamine binds to the phosphate backbone of dna using the argininerich domain as an anchor. Always seek specialist haematologist advice before administering protamine as in most. Dna is then folded into a toroid, an oshaped structure, although the mechanism is not known.
Adverse reactions to protamine sulfate following cardiac surgery. Protamine is classified as fda pregnancy risk category c. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Other information additional information about no data available. Dailymed protamine sulfate protamine sulfate injection. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously. Dobutamine in 5% dextrose injection, usp flexible plastic. However, the significance of these findings in routine clinical use is not known. Rapid disappearance of protamine in adults undergoing cardiac. Protamine definition of protamine by merriamwebster. It is not known whether protamine sulphate is distributed into breast milk and the drug should be used with caution during lactation. Dobutamine in 5% dextrose injection, usp is a sterile, nonpyrogenic, prediluted solution of dobutamine hydrochloride and dextrose in water for injection. Protamine definition of protamine by the free dictionary. Preliminary studies indicate that the concomitant use of dobutamine and nitroprusside results in a higher cardiac output and, usually, a lower pulmonary wedge pressure than when either drug is used alone.
The amount of protamine required decreases over time as heparin is metabolized. The following are the supplementary data related to this article. Pdf the important role of protamine in spermatogenesis. Protamine dosing guidelines guidelines for unfractionated heparin. Caution should be observed when administering protamine sulfate to patients who may be at increased risk of allergic reaction to protamine. Microsoft word allows you to create a variety of documents for practically every aspect of your business. Fertility studies have not been performed to date with protamine sulphate to determine the effect of the drug on fertility. It is not known if protamine can cause fetal harm when administered to a pregnant woman. Stat protamine sulfate see dosing recommendations below time from last dose of enoxaparin protamine sulfate dose less than 8 hours 1 mg protamine for every 1 mg of enoxaparin.